RESUMO
BACKGROUND: The crossed cerebro-cerebellar (CCC) activation facilitates the diagnosis of cortical language lateralization, but needs to be explored with language tasks suitable for patients with different age ranges, educational attainment and eventual presence of language deficits. AIM: To determine the effect of demographic variables in the performance of three language tasks in healthy volunteers and to determine the CCC activation of these tasks as a functional magnetic resonance imaging (fMRI) paradigm in brain tumor patients. MATERIAL AND METHODS: The behavioral performance (correct responses and reaction time) of three language tasks (verbal fluency, semantic and phonological decision tasks) was first examined in 76 healthy volunteers balanced by age and educational level. Later, these tasks were implemented as fMRI paradigms to explore CCC language activation of 20 patients with potential diagnosis of brain tumors. RESULTS: The performance of the verbal fluency task was affected by age. The CCC language activation was reproducible with the semantic and phonological tasks. The combination of the tasks determined typical and atypical language lateralization in 60% and 40% of our patients, respectively. CONCLUSIONS: The verbal fluency task must be implemented with care as a clinical fMRI paradigm. Our results suggest that semantic and phonological tasks can be a good alternative for brain tumor patients with language deficits.
Assuntos
Neoplasias Encefálicas , Idioma , Encéfalo , Mapeamento Encefálico , Neoplasias Encefálicas/diagnóstico por imagem , Lateralidade Funcional , Humanos , Imageamento por Ressonância MagnéticaRESUMO
Background: The crossed cerebro-cerebellar (CCC) activation facilitates the diagnosis of cortical language lateralization, but needs to be explored with language tasks suitable for patients with different age ranges, educational attainment and eventual presence of language deficits. Aim: To determine the effect of demographic variables in the performance of three language tasks in healthy volunteers and to determine the CCC activation of these tasks as a functional magnetic resonance imaging (fMRI) paradigm in brain tumor patients. Material and Methods: The behavioral performance (correct responses and reaction time) of three language tasks (verbal fluency, semantic and phonological decision tasks) was first examined in 76 healthy volunteers balanced by age and educational level. Later, these tasks were implemented as fMRI paradigms to explore CCC language activation of 20 patients with potential diagnosis of brain tumors. Results: The performance of the verbal fluency task was affected by age. The CCC language activation was reproducible with the semantic and phonological tasks. The combination of the tasks determined typical and atypical language lateralization in 60% and 40% of our patients, respectively. Conclusions: The verbal fluency task must be implemented with care as a clinical fMRI paradigm. Our results suggest that semantic and phonological tasks can be a good alternative for brain tumor patients with language deficits.
Assuntos
Humanos , Neoplasias Encefálicas/diagnóstico por imagem , Idioma , Encéfalo , Mapeamento Encefálico , Imageamento por Ressonância Magnética , Lateralidade FuncionalRESUMO
Este trabajo presenta la experiencia de 64 pacientes tratados con abordaje supraorbitario lateral (key hole): 33 pacientes con hidrocefalia en los que se realizó fenestración de la lamina terminalis, 11 pacientes con extirpación de tumores de base de cráneo, 20 pacientes con aneurisma cerebral de circulación anterior. Se describen algunas modificaciones en la técnica quirúrgica, complicaciones y seguimiento.
This works presents the experience of 64 patients treated with supraorbital approach (key hole): 33 with hydrocephalus in which was performed the fenestration of the lamina terminalis, 11 with cranial basal tumors, 20 with anterior circulation aneurysm. Some modification of the technique, complications and medical following are described.
